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Istradefylline forty mg/day amplified peak concentrations and AUC of CYP3A4 substrates in medical trials. This effect wasn't observed with istradefylline 20 mg/working day. Contemplate dose reduction of delicate CYP3A4 substrates.Impact of coadministration of a dual CYP3A4 and CYP2C19 inhibitor with fedratinib hasn't been studied.Modafinil was not